Lung Cancer Cell Lines

Small cell lung cancer project site navigation project documentation data downloads.

Lung cancer cell lines.

Browse squamous cell adenocarcinoma sclc and nsclc cell lines for drug response toxicology in vitro models including a549 nci h292 and more. Lung cancer and normal cell lines atcc no. Adi gazdar and john minna pioneered the derivation of lung cancer cell lines during their tenure at the national cancer institute during the 1970s and 1980s and continued to pursue this effort when they moved to ut southwestern in 1991. They successfully established over 200 lung cancer cell lines encompassing many.

Select lung cancer cell lines authenticated by ecacc based on associated mutations and diagnosis classifications. Through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58 year old caucasian male. All experiments should include physiologically relevant controls. 1 3 despite response rates of 60 to 65.

The cells are used as models for the study of lung cancer and the development of drug therapies against it. Non small cell lung cancer is an umbrella term for several types of lung cancers. Non small cell lung cancer. Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived.

Lung cancer cell lines eml4 alk fusion a549 a549. By default data for all cell lines will be retrieved though search results can be restricted by panels or cell lines in the next part of the form. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. When you inhale cigarette smoke which is full of cancer causing substances carcinogens changes in the lung tissue begin almost immediately.

Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung. Standard of care first line treatment for extensive stage small cell lung cancer is platinum chemotherapy carboplatin or cisplatin with etoposide. A549 cells are adenocarcinomic human alveolar basal epithelial cells and constitute a cell line that was first developed in 1972 by d. Lung cancer cell lines.

Physiologically relevant controls. Atcc provides both primary and htert immortalized bronchial epithelial cells and small airway cells that may be used side by side with nsclc or sclc cells as normal controls. Doctors believe smoking causes lung cancer by damaging the cells that line the lungs. At the time of diagnosis 2 out of 3 people with sclc are already in the extensive stage.